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Sensors & Electronics

Biolgical Sensors

Enzyme Immobilization for Chem-Bio Sensors (288)

Problem: Need to immobilize and increase effective lifetime of enzymes to improve the efficacy of enzyme-based sensors

Graphic of enzymes stabilized in surface activated mesoporous silica structure

Project Activity Scope (from Technical Overview Chart): Mechanisms through Sensors and Devices

PNNL Solution:

  • Enzymes stabilized in surface activated mesoporous silica structure exhibit activity increased from hours to over 6 months
  • Successfully demonstrated with multiple enzymes to increase activity significantly
  • Target applications are small, robust, sensitive detectors and reactors

Capabilities Employed to Meet Client Needs: Mesoporous surfaces, surface functionalization chemistry, enzyme modification, bio-structural modeling, fluorescence chemistry, electro-chemistry.

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Contact: Eric Ackerman

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